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Clinical and Laboratory Standards Institute document I/LA31-A–Newborn Screening for Preterm, Low Birth Weight, and SickNewborns; Approved Guideline addresses newborn screening of preterm, low birth weight (LBW), and sick newborns worldwideto detect treatable conditions before physical damage can occur to the infant. In developed countries, advances in the treatmentthey receive have improved survival rates, making the early detection of conditions detected by newborn screening even moreimportant. The physiological states associated with preterm, LBW, and sick newborns, and the treatments they receive, directlyaffect the reliability of results for many conditions screened in public health dried blood spot and newborn hearing screeningsystems. This guideline describes the effects of maternal and infant conditions, as well as treatments given to newborns. It alsoprovides the rationale for the recommended intervals for screening designed to minimize the risk of missing or delaying adiagnosis in an affected newborn. It is intended for use by those involved in any aspect of newborn screening specimen collectionor hearing screening testing and follow-up, including health care providers, parents, public health professionals, and othersconcerned with the health and welfare of newborns.

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